(from the chapter) In this chapter, I review prevention and intervention efforts for addictive behaviors in the college setting within the context of the addiction syndrome model. By definition, a syndrome is a cluster of related symptoms with a distinct temporal progression (Kandel & Raveis, 1989), and the manifestation of an addiction syndrome in the college setting provides a unique and timely opportunity for prevention and intervention. I first focus on a few common prevention efforts in the college setting for multiple addictive behaviors-alcohol use, smoking, marijuana use, and gambling. Second, I review the relationship between specific components of the addiction syndrome model (i.e., shared psychosocial antecedents, shared experiences, concurrent manifestation of addictive behaviors, and addiction hopping) and existing prevention and intervention efforts. Finally, I suggest some promising directions for future research in this population that may further elucidate the existence of the addiction syndrome.