Commentary on Boileau et al. (2013): Distinguishing D2/D3 dopaminergic contributions to addictions


Comments on an article by Isabelle Boileau et al. (see record 2013-13597-022). Boileau et al. addressed clinically and scientifically important topic of the role of dopamine D2-like receptors in pathological gambling (PG). Given the importance of dopaminergic projections from the ventral tegmental area to ventral striatum in substance addictions, it was reasonable to hypothesize a similar involvement in PG. The absence of between group differences in D2/D3 11C]-raclopride binding is consistent with findings from two other studies of community PG subjects, although one study suggested a between-group difference among individuals performing less advantageously on the Iowa Gambling Task. In addition to allowing for detailed associations between neurotransmitter systems and behavior, dual radiotracer approaches may provide insight into receptor profiles of antipsychotic and antidepressant medications, yielding more detailed accounts of receptor occupancies in vivo. Thus, the use of more than one radiotracer in a single study to gain detailed information about neurotransmitter systems of known importance is a novel area of research for which the Boileau et al. study is a strong addition to the field of PG. (PsycINFO Database Record (c) 2013 APA, all rights reserved)

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