How central is dopamine to pathological gambling or gambling disorder?


Pathological gambling (PG) characterized by maladaptive patterns of gambling that are associated with significant impairments in functioning. Multiple neurotransmitter systems have been implicated in PG including serotonergic, noradrenergic, dopaminergic, opioidergic, and glutamatergic. An understanding of these systems as they relate to PG is important clinically for drug development as presently there are no FDA-approved medications with indications for PG. In this opinion article, the authors examine the role of dopamine in PG

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