Opioid and dopamine mediation of gambling responses in recreational gamblers


Comments on an article Opioidergic and Dopaminergic Manipulation of Gambling Tendencies: A Preliminary Study in Male Recreational Gamblers by R. Porchet et al. (2013). The study by Porchet and colleagues examined the roles of dopamine and the endogenous opioids in response to tasks designed to evoke gambling-related cognitive distortions in recreational gamblers. The results report where as the effects in recreational gamblers reflect a perturbation from homeostatic baseline function, the increase in dopamine cell firing induced by haloperidol and increase in stress axis responding induced by naltrexone may act to restore or mitigate deviations from normal brain function that represent the new baseline or "allostatic" brain state of the pathological gambler. (PsycINFO Database Record (c) 2014 APA, all rights reserved)

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