The purpose of this paper was to examine risk and protective factors associated with the consequences of card gambling and commercial gambling for Indigenous Australians in north Queensland. With Indigenous Elders' approval and using qualitative methodology, semi-structured interviews were conducted with 60 Indigenous and 48 non-Indigenous Australians in three north Queensland sites. Risk factors associated with both card and commercial gambling consequences were found to be poverty and a reluctance to seek gambling help, while for card gambling only, generational influences was a risk factor. In contrast, protective factors for both card and commercial gambling consequences were reported as positive role models, family relatedness and cultural resilience. Culturally distinctive risk and protective factors, once identified, can be the target of public health strategies to promote responsible gambling awareness among Indigenous gamblers.